Of mice and men, metals and mutations.

O-2: A Novel Antioxidant Formulation to Treat Male Infertility Emanating from Sperm Oxidative DNA Damage: Promising Preclinical Evidence from Mouse Models

Background: Sperm DNA damage (SDD) is a significant male infertility factor, yet it is not routinely diagnosed or treated in couples undertaking fertility treatment by ART. Men with this condition are likely to experience sub-fertility or infertility, expose their female partners to greater risk of miscarriage and pass on de novo sporadic DNA mutations potentially compromising the health of the...

C26232T Mutation in Nsun7 Gene and Reduce Sperm Motility in Asthenoteratospermic Men

Reduced sperm quantity and motility are primary causes of infertility in men. Before researchers showed that, Nsun7 gene has roles in sperm motility of mouse, that creation defect in this gene is cause infertility. This gene in human located in chromosome 4, with 12 exons and a hot spot exon (exon7). Our aim is study of the mutations of the exon7 in the normospermic and asthenoteratospermic men...

Mitochondrial Genetic Variation in Iranian Infertile Men with Varicocele

Objective Several recent studies have shown that mitochondrial DNA mutations lead to major disabilities and premature death in carriers. More than 150 mutations in human mitochondrial DNA (mtDNA) genes have been associated with a wide spectrum of disorders. Varicocele, one of the causes of infertility in men wherein abnormal inflexion and distension of veins of the pampiniform plexus is observe...

FABP9 Mutations Are Not Detected in Cases of Infertility due to Sperm Morphological Defects in Iranian Men

Screening of two closed mutations in CFTR gene of Iranian infertile men with non-obstructive azoospermia

Background The genetic association between cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations and male infertility due to congenital bilateral absence of vas deferens (CBAVD) is well established. Mutant CFTR, however may also be involved in the etiology of male infertility in non-CBAVD cases. The present study was conducted to estimate the frequency of ΔI507 and ΔF508 CFT...

P-213: Mutation Analysis of Mitochondrial ND4L Gene in Iranian Infertile Men with Varicocele

Background: Varicocele is the abnormal tortuosity and dilatation of the veins of the pampiniform plexus within the spermatic cord. Varicocele-related pathology is suspected in infertility as it leads to elevated temperatures in the scrotum and testes, which has a deleterious effect on spermatogenesis. In Varicocele patients, ROS production is enhanced and total antioxidant capacity (TAC) is red...